KH 176( KH176 )

Catalog No. M13449 CAS No. 2162149-24-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

KH 176
Note

Research use only, not for human use.
Brief Description

KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator.
Description

KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders; retains brain microstructural coherence in the external capsule in Ndufs4 -/- mice and normalizes the increased lipid peroxidation in this area and the cerebral cortex, significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice.Other Indication Phase 2 Clinical.
In Vitro

——
In Vivo

Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4?/? mice. Animal Model:Ndufs4?/? mice (Leigh Disease model).Dosage:10?mg/kg.Administration:IP, daily (PD14-PD45, 32 days).Result:Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells.Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.
Synonyms

KH176
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Other Indications
Indication

Other Disease

CAS Number

2162149-24-6
Formula Weight

368.902
Molecular Formula

C19H29ClN2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 170 mg/mL (460.83 mM)
SMILES

——
Chemical Name

(S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2-carboxamide hydrochloride

1. de Haas R, et al. Sci Rep. 2017 Sep 15;7(1):11733. 2. Koene S, et al. Orphanet J Rare Dis. 2017 Oct 16;12(1):163.

Calculator

molnova catalog