KH 176

Research use only, not for human use.

KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator.

KH176 is a chemical entity derivative of Trolox and small molecule ROS-redox modulator, shows potential treatment for mitochondrial disorders; retains brain microstructural coherence in the external capsule in Ndufs4 -/- mice and normalizes the increased lipid peroxidation in this area and the cerebral cortex, significantly improves rotarod and gait performance and reduces the degeneration of retinal ganglion cells in Ndufs4 -/- mice.Other Indication Phase 2 Clinical.

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Sonlicromanol (KH176) hydrochloride maintains microstructural coherence in the brain of Ndufs4?/? mice. Animal Model:Ndufs4?/? mice (Leigh Disease model).Dosage:10?mg/kg.Administration:IP, daily (PD14-PD45, 32 days).Result:Significantly improve rotarod and gait performance and reduced the degeneration of retinal ganglion cells.Resulted in statistically significantly higher FA values in the external capsule and a similar trend was found in the cerebral peduncle.

KH176

Others

Other Targets

Other Targets

Other Indications

Other Disease

2162149-24-6

368.902

C19H29ClN2O3

>98% (HPLC)

In Vitro:?DMSO : 170 mg/mL (460.83 mM)

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(S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)-piperidin-3-yl)chroman-2-carboxamide hydrochloride

(-20℃)

With Ice Pack

≥ 2 years